The Massachusetts Taxpayer’s Foundation (MTF) believes that all segments of our society must rally together to reverse the trends and relieve the human suffering and economic burden of this expanding epidemic. One way to increase cohesion and focus among all stakeholders in this battle is to provide a comprehensive picture of the size and scope of this epidemic. This report endeavors to accomplish this by measuring the drag on the Commonwealth’s economic growth and by quantifying the costs to employers, health care providers, and state and municipal budgets trying to cope with the consequences of opioid addiction.